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In fact, major depression is a common side effect of this disease: one study indicated that over 20% of the pancreatitis patients suffering from constant, severe pain reported using antidepressants to manage their depression concomitant to pain [14]

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83 Furthermore, hypoxia-induced lactylation of β-catenin in CRC cells enhances the protein stability and expression of β-catenin, which is associated with the inhibition of protein degradation