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It is speculated that altering the thyroid iodine metabolism by affecting the NIS expression and activity could be a potential pathway for lipopolysaccharides (LPS) and short-chain fatty acids (SCFAs) released by the gut microbiota ( In addition to iodine, selenium is also detrimental to thyroid homeostasis, which is found in higher concentrations in the thyroid gland in comparison to any other tissue in the human body ( via an increased expression of Pax8 and promoting its binding to the upstream enhancer region of the NIS, which is assumed to be due to enhanced selenium uptake to activate NIS promoter and hence induce NIS transcription ( Lactobacillus converts intracellular sodium selenite into selenocysteine and selenomethionine, thus facilitating the absorption of selenium into the human body as organic selenium ( Conversely, selenium has also been reported to alter the diversity and composition of gut microbiota in mice ( The role of microbiota in iodothyronine metabolism It has been revealed that thyroid hormone homeostasis is closely related to the effect of gut microbiota on iodothyronine metabolism
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Affecting approximately 2–3% of the global population, Psoriasis significantly impacts patients’ quality of life and is often associated with comorbid conditions such as psoriatic arthritis, cardiovascular diseases, or metabolic syndrome
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