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Peptide allergies It’s possible to become allergic to peptide coupling agents, which are necessary parts of synthetic peptide manufacturing.18 19 The risk is much higher in researchers who frequently handle or are exposed to these compounds, but since peptide coupling agents are described as “immune sensitizers,” it stands to reason that the risk, albeit small, applies to everyone.18 “Copper peptide uglies” Anecdotal reports suggest that some people may experience worsened skin aging, instead of anti-aging, after using products with GHK-Cu — a rare condition known as “copper peptide uglies.” It isn’t necessarily a safety issue, but it’s still a potential downside of using copper peptide products

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doi: 10.1111/j.1749-6632.2012.06574.x