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Following Coley and Ehrlich, sequential efforts for the development of many cancer therapeutics took place in the 1900s, including DNA analogs, antimetabolites, cytotoxic molecules, protein tyrosine kinase inhibitors, and finally, monoclonal antibodies [3]
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[DOI] [PubMed] [Google Scholar] 17.Robert A., Nezamis J.E., Lancaster C., Hanchar A.J