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Since Ruminiclostridium 6 was only observed in the LD control group, it was unsurprising that its relative abundance was significantly greater in this group compared to all other experimental groups (Supplementary Fig
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In particular, the consumption of extra virgin olive oil is associated with a risk reduction of certain cancers supported by several epidemiological studies in human beings ( Regarding the cancer chemo-preventive activities, it has been shown that HOTYR is able to inhibit both initiation and promotion/progression phases of carcinogenesis by preventing the DNA damage induced by different genotoxic molecules and by inhibiting proliferation and inducing apoptosis in different tumors cell lines, respectively ( The role of HOTYR as a chemo-preventive anti-carcinogenic compound has received attention in human carcinoma cells in many in vitro studies showing significant effects in several cancer cell lines as main responsible compound, either alone or in a synergistic manner (2)
