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Understanding the Innate Repair Receptor (IRR) The innate repair receptor is a heteromeric receptor complex composed of: Erythropoietin receptor (EPOR) β-common receptor (CD131) This receptor is activated in response to: Tissue injury Hypoxia Inflammation Oxidative stress Activation of the IRR triggers a cascade of protective signaling designed to: Limit tissue damage Reduce inflammation Promote cellular survival Support repair rather than scarring ARA-290 was designed specifically to activate this receptor without activating erythropoiesis

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The LR3 modification (13-amino-acid N-terminal extension plus Glu3Arg substitution) reduces affinity for IGFBP-1 through IGFBP-6 by roughly 2 to 3 orders of magnitude compared to native IGF-1, according to biochemical binding studies