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Secondly, the persistently high level of LH secretion promotes ovarian stromal vascular proliferation, increased stromal blood flow, enhanced oxygen metabolism, and increased production of reactive oxygen species (ROS), triggering oxidative stress, which adversely affects oocyte maturation, fertilization, embryo development, and the progress of pregnancy (Awonuga et al., 2023)
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In animal models, Tesamorelin's enhanced stability allows for a more sustained stimulation of the GHRHR compared to native GHRH, which has an extremely short half-life