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Because measurement of pyroglutamic acid is only available in specialised metabolic laboratories, it can be difficult to confirm the diagnosis of PGA

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Complementing this approach, researchers have also designed enzyme-responsive self-assembled multivalent apelin ligands (SAMPs), which achieve targeted accumulation at the myocardial infarction site by responding to locally upregulated matrix metalloproteinases, thereby prolonging retention time and enhancing receptor binding affinity (81)